Ketoconazole 200 mg is an azole medicine used to treat fungal infections. It is effective against a broad spectrum of fungi including dermatophytes and yeasts such as candida.

This medicine is an antibiotic that fights against fungal infections. The brand name of the ketaconazole is Nizoral and it is a lipophilic medicine. This lipophilic is leading to the accumulation of fatty tissues. The less toxic and more effective compounds such as fluconazole, itraconazole etc are used to replace the ketoconazole for internal purpose. The medicine is having the ability to absorb the highly acidic levels.

The active ingredient Ketoconazole has some antiandrogenic effects, but it is unknown whether the amount in the shampoo is absorbed. If it helps with hairloss it may work in a way other than as an antiandrogen. It is definitely a good shampoo for making hair look thicker.

Infection with fungi

Many treatments are taken by using ketoconazole and the patient should follow their doctor�s prescription. This drug can be used with or without food and the tablets of ketoconazole needs acidity in stomach for dissolving. Therefore, the patient should be taken antacids or acid inhibiting medications at least two hours after using ketoconazable.

Ketoconazole binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall. The medication is somewhat better absorbed orally when it is taken with a fatty meal or acidic drink (e.g. orange juice). It is bound to proteins such as albumin in the circulating blood and is widely distributed in body tissues. It takes three to ten hours for half of the medication to be cleared from the blood stream. The rest is eliminated in faeces and urine either unchanged or after conversion by the liver into inactive compounds.

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As ketoconazole needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after ketoconazole. Ketoconazole interacts with alcohol rather like disulfiram and can cause severe nausea and vomiting.

Fungi that cause infections in humans are known as dermatophytes. Therefore in order to feed, fungi have to break down living tissue, including human tissue. People with a weakened immune system are particularly vulnerable to invasive fungal infections.